Some diseases cannot be ignored because of their obvious, visible symptoms. One of these problems is onychomycosis. Nail fungus deforms them appearance causes itching and discomfort in the feet and hands. In the article we will consider in detail effective ways fight against onychomycosis.

You can approach the treatment of onychomycosis using several approaches. Both local remedies are recommended - ointments, creams and nail polishes, as well as systemic preparations. In addition, it is imperative to follow lifestyle recommendations. Nail fungus is not a fatal disease. It responds well to treatment if the treatment is properly prescribed and all necessary measures are observed.

Important! The most common causative agent of onychomycosis, the fungus Trichophyton rubrum, causes 90% of all fungal infections.

Ointments, creams, sprays

All ointments and creams for onychomycosis require long-term use, since the active substance must accumulate in the plate in an effective concentration. You can talk about the final cure after the growth of a healthy nail. Means differ in the active antimycotic component.

One of the most effective remedies for onychomycosis today. Terbinafine is included in clinical guidelines for the treatment of fungal infections.

Based on it, a number of drugs are produced:

  • Lamisil;
  • Fungoterbin;
  • Exifin;

All agents are applied twice daily until clinical and laboratory cure. Beforehand, hands or feet should be thoroughly washed and dried.

Naftifin

Exists only in the form of one drug - a cream, ointment or Exoderil solution. It effectively helps with onychomycosis and mycosis of the feet and hands. Exoderil is used once or twice a day until a healthy regrowth nail plate. You should not stop treatment earlier, as there is a high risk of recurrent fungal infection.

Important! Exoderil is contraindicated in pregnant and lactating women.

It is used for onychomycosis in a long course once a day. The manufacturer recommends that after the growth of a clean nail, apply the product for another two weeks. This will avoid relapse.

Bifonazole is contained in the composition of the funds:

  • Bifunal cream or spray;
  • Bifosin cream or spray;
  • Mycospor cream or solution.

Sertaconazole

A modern antimycotic agent, which is contained in the composition of just one drug - Zalain cream.

Zalain cream is a broad-spectrum antifungal drug that kills skin fungus of any localization.

Sertaconazole has a wide spectrum of activity, it is effective against several types of fungi. With onychomycosis, it is recommended to apply twice a day to the affected nail plate. The course of treatment is at least a month.

One of the best known antifungal drugs, it is still used in the treatment of athlete's foot. It is used twice a day, applied to the affected nails, covering the skin around.

Clotrimazole-based products differ in manufacturer and price.

This is a broad-spectrum antifungal drug, so you can find shampoos, creams, ointments and sprays with ketoconazole on sale. They effectively get rid of dandruff, fungal infections of smooth skin and onychomycosis. A ketoconazole-based Nizoral cream is used twice a day until a healthy nail grows.

Important! Any local remedy can cause an allergic reaction: if there is a burning sensation and redness, the drug should be washed off.

Lucky

As one of the options for external therapy for onychomycosis, nail polishes are used. The drug is applied to the affected surface, covering it completely. The antimycotic effect is provided by the active substance: amorolfine or ciclopirox.

An effective antifungal agent that actively accumulates in the nail plate. Amorolfine penetrates deep into, persists for 7-10 days, therefore daily application not required. Main disadvantage drugs based on amorolfine- high cost, which is somewhat different for different manufacturers.

In addition to the bottle with the drug, the kit includes files for removing the affected part of the nail, spatulas for applying the drug and alcohol wipes for pre-treatment of the nail.

The manufacturer recommends using preparations with 8% ciclopirox solution for 24 weeks. In this case, the first month it is necessary to apply the product every other day, the second month twice a week and then once a week from the growth of a clean nail. The total duration of treatment should be at least 6 months.

Preparations containing ciclopirox:


Systemic drugs

With significant fungal lesions, only external therapy is not enough. In such cases, it is recommended systemic antifungals.

All systemic drugs have a toxic effect on the liver, therefore, before their appointment, it is recommended to examine the therapist and conduct liver tests. If transaminases deviate from normal, as well as in a number of chronic diseases, systemic drugs are contraindicated.

The fungus can persist on clothes and shoes, causing a recurrence of the disease. Therefore, it is important, in parallel with antifungal agents, to carry out antimycotic treatment of shoes, socks, tights during the entire course of treatment once a month.


Attention should be paid to the condition of the feet. Increased sweating, the smallest cracks, rare hygiene procedures - all this is fertile ground for the fungus. Feet should be washed regularly, 1-2 times a day, using a non-irritating soap. After hygiene procedures, be sure to dry the skin well, it is advisable not to put on socks immediately.

Avoid synthetic, nylon tights and socks, as they do not allow the skin to breathe and create a greenhouse effect. The skin actively sweats, the risk of a fungal infection increases. Shoes made of synthetic non-breathable fabrics have a similar effect.

Before applying external antifungal drugs, the affected limbs should be steamed in a bath with soap and a small amount of baking soda. This soap and soda treatment allows you to soften the affected nails. After that, the nail is cut off as much as possible and sawed off. It is recommended to steam the nails in the bath once a week. All means must be individual: basin, nail files, scissors, shoes.

Important! For the period of treatment, visits to public baths and pools are contraindicated.

Choice of treatment

Tactics for each specific case of onychomycosis will be different. The choice of therapy depends on:

  • area of ​​the affected nail;
  • skin involvement;
  • associated pathologies;
  • responsibility of a person, his readiness for regular nail treatments.

If the fungus has affected no more than a third or half of the nail plate of one or two fingers, then only local remedies are recommended. In this situation, creams, ointments and nail polishes will be effective. Systemic drugs are not indicated.

In some cases, a person is not ready for regular treatment of the nail plates. Treatment of onychomycosis is always a long process, which usually lasts about six months or more. Therefore, some people prefer oral antimicrobial topical therapy because they are not time consuming.

However, there is also a reverse situation, for example, pregnancy or severe somatic pathology (liver failure) in combination with a fairly common onychomycosis. In such a situation, tableted antimycotics are undesirable. Therefore, local forms are recommended: creams and varnishes.

When choosing between creams and varnishes, it should be borne in mind that creams and ointments tend to be absorbed for a long time. At least 15-30 minutes after application, it is undesirable to wear shoes or socks, as the product is smeared. In addition, the drug can contaminate clothing. In this regard, varnishes have a clear advantage: they dry on the surface of the nail in a couple of minutes, allowing people who are actively working and studying to live a full life.

But with a combined lesion, when there is onychomycosis and mycosis of smooth skin, nail polish alone will not be effective enough. You will need an additional cream or systemic antifungal agent.

Fungal nail infections are one of the most common in dermatological practice. Treatment is not difficult, however, due to the long regrowth of the nail plate, it turns out to be delayed in time. Proper adherence to recommendations for nail care in combination with antimycotic therapy allows you to permanently get rid of the fungus. In the future, advice on foot hygiene and the preventive use of antifungal agents at each visit to saunas, baths, and pools remain relevant.

Video - Treatment of onychomycosis


The provides paper the data on the pathogens of onychomycosis and the clinical types of nail affections and describes the current treatments of onychomycosis with highly effective systemic and topical antifungal agents. The paper also shows that cure may be achieved by the correct choice of antimycotic agents by taking into account the type and form of affection, the extent of the process, as well as the patient's health status (the presence of concomitant diseases, immunity ).

Zh. V. Stepanova - Central Research Institute of Dermatovenereology, Ministry of Health of the Russian Federation, Moscow.
Zh.V. Stepanova - Central Research Dermatovenereological Institute, Ministry of Health of the Russian Federation, Moscow

IN For the past 20 years, mycoses of the feet (hands) have been the most common fungal diseases in all countries of the world, while nail plates are also affected in 40% of cases.
Onychomycosis can be caused by dermatophytes, yeast-like and mold fungi. Of the dermatophytes, the main causative agent is considered
Trichophyton rubrum isolated during culture in 60 - 70% of cases. The fungus can affect the nail plates on the toes, hands, smooth skin in any area skin, as well as long and vellus hair. The second stimulus Trichophyton mentagrophytes var. interdigitale affects the nails of the feet only on the I and V fingers and the skin of the III - IV interdigital folds, the upper third of the sole, the lateral surfaces of the foot and fingers and the arch of the foot. Very rarely causes damage to the nails on the I and V toes of the feet fungus Epidermophyton floccosum. However, onychomycosis is often caused by mixed flora: dermatophytes and yeast-like or mold fungi, possibly attaching a bacterial infection. From mold fungi the most common causative agent is a fungus Scopulariopsis brevicaulis, causing, as a rule, damage to the nails on the big toes, while the nails become Brown color. Less commonly, moldy onychomycosis can be caused by fungi of the genusAspergillus, Alternaria, Acremonium, Fusarium and etc.
Nail damage caused by dermatophytes can be distal, when the change in the nail starts from the free edge, lateral and proximal.
Observed several forms of nail damage in onychomycosis: normotrophic,in which the normal configuration of the nails is preserved, but they become dull, with a yellowish tinge at the free edge, with a thickening in the corners of the nail plate due to the accumulation of horny masses; hypertrophic- thickening of the nail over the entire surface due to subungual hyperkeratosis, the nails become dull, dirty gray, loosened at the free edge; atrophic- the nails are significantly destroyed, as if corroded from the free edge, the nail bed is partially exposed, covered with a layer of loose and dry crumbling masses; defeat by type onycholysis- the nail plates are separated from the nail bed, become dull, sometimes dirty gray in color, the normal color of the nail remains at the base. There may be a combined lesion of the nails in one patient.
Behind last years significant progress has been made in studying the causes of onychomycosis, in particular, the possibility of spreading Trichophyton rubrum by the lymphatic route.
Trichophyton rubrum And Trichophyton interdigitale can cause an allergic restructuring of the body, in addition, dermatophytes and some mold fungi can have a toxic effect on the body.

Treatment of onychomycosis

Currently, mycologists have a wide range of antifungal drugs for systemic and external action in various dosage forms (ointment, cream, solution, varnish, powder). However, the problem of treating patients with onychomycosis is still relevant, since relapses of the disease are often observed, candida onychia is difficult to treat.
When recommending a treatment method to a patient, it is necessary first of all to take into account its therapeutic efficacy, safety, method of application, and also cost.
To obtain a therapeutic effect, antimycotics with a fungicidal effect on various types of pathogens, the ability to accumulate in the nail matrix and nail bed, are preferred. An important point is the way the drug is used.
When choosing a treatment method, it is necessary to take into account the type and form of the lesion, the degree of spread, the duration of the disease, the rate of nail growth and the general condition of the patient (the presence of concomitant diseases, the state of the immune system, etc.).

Treatment with antimycotics systemic action

Treatment with systemic antimiotics is carried out without removing the nail plates.
Daily dose terbinafine for adults 250 mg, taken 1 time per day or 125 mg 2 times a day during or after meals daily. The duration of treatment is from 6 weeks to 3 months. and depends on the age of the patient, the shape and area of ​​the lesion. It is possible to reduce the duration of treatment if the horny layers are mechanically removed, especially in the hypertrophic form.
In the first days of treatment, side effects such as nausea, discomfort or discomfort in the gastrointestinal tract are possible. Contraindications to the appointment of terbinafine are pregnancy and individual sensitivity to the drug.
With onychomycosis of the feet (hands), caused by dermatophytes, molds, yeast-like fungi and mixed flora, treatment can be carried out itraconazole, it is prescribed by an intermittent method: 200 mg (2 capsules) 2 times a day after meals for 7 days, then a 3-week break is made. With onychomycosis caused by dermatophytes or yeast-like fungi, 3-7 day cycles are sufficient, with moldy onychomycosis - 2-3 cycles, 4 cycles of therapy should be carried out in elderly patients and with slow growth nails. With onychomycosis of the hands, especially in faces young age, the therapeutic effect can be obtained during 2 cycles of therapy.
Studies of the pharmacokinetics of itraconazole in the nail tissue found that the drug penetrates into the nail plate through the nail matrix, as well as by diffusion from the nail bed and persists in the focus of infection for 6 months. after the end of treatment during 3 cycles. The duration of treatment depends on the area of ​​damage to the nail and the rate of growth of the nail plate.
It is not recommended to prescribe treatment with itraconazole for patients with onychomycosis with impaired liver and kidney function, pregnant and lactating women. With reduced acidity of the stomach, corrective therapy is prescribed. Itraconazole is well tolerated. Side effects are possible, but rarely (gastrointestinal disturbances, skin itching, fatigue, heaviness in the head), they disappear without discontinuation of the drug.
With candidal paronychia and onychia, treatment is effective fluconazole. The drug is prescribed 200 mg per day after meals (double dose of 400 mg on the first day) daily for 3-4 months. Fluconazole therapy can be combined with topical antifungals: bifonazole, ciclopirox, clotrimazole, isoconazole in the form of a cream or solution. Bifonazole is rubbed into the area of ​​​​the roller 1 time in the evening, the rest of the drugs - 2 times a day.

Local therapy

If there are contraindications to the use of systemic antimycotics, bifonazole cream in the kit for treating nails in combination with 1% bifonazole cream, 5% amorolfine lacquer, 8% ciclopirox lacquer can be prescribed to patients with onychomycosis of the feet (hands).
Treatment with bifonazole cream in the nail treatment kit consists of two stages. At the first stage, the affected nails are removed using a cream consisting of bifonazole and urea. The cream is applied to the areas of the affected nails under an occlusive dressing using a dispenser, distributed over the surface of the nail and left for 24 hours under a waterproof plaster. Before the next application of the cream, the bandage is changed, a warm bath is made and the easily detachable part of the affected nail is removed with a special file. Application creams continue until the nail plate or part of it is removed. Our results showed that with the help of this dosage form, it is possible to painlessly remove the nail plate in layers within a period of 4 to 28 days (on average after 16 days), while the nail bed is being treated at the same time. The patient must be warned that the removal of the nail should be carried out only according to the specified method and that the blade should not be used. Subsequent therapy consists in treating the bed with 1% bifonazole cream for 4 weeks or more, depending on the degree of damage to the nail. The cream is rubbed into the bed once a day, at the same time it is applied to the skin of the feet and interdigital folds in the evening after washing the feet and drying them. Clinical observation and mycological studies are carried out before the start of treatment, after detachment of the nail, at the end of treatment, then after 1, 3, 6, 12 months. after the end of treatment. With the distal type of lesion, the growth of healthy nails is observed from 1.5 to 4 months, with the distal-proximal from 6 to 12 months, however, not all patients recover, with the proximal type there is a clinical improvement. It should be noted that bifonazole cream for the treatment of nails is well tolerated, which makes it possible to use this method in patients with onychomycosis. and foot eczema. You can simultaneously treat eczema. Bifonazole nail cream can be widely used in elderly patients.
With onychomycosis caused by dermatophytes, yeast-like and mold fungi, with a lesion area of ​​​​up to 80%, an intact hole and a nail bed, you can use 5% varnish and 0.25% amorolfine cream. Nail polish is applied to the affected nails of the toes or hands once every 7 days. Before applying it, it is necessary to remove the affected areas of the nail with the file attached to the varnish. Then clean and degrease the surface of the nail with a swab moistened with alcohol.
With repeated use of varnish, the infected areas of the nails are again removed with a file. Before processing, it is necessary to remove the remnants of varnish from the nails with a swab, soaked in alcohol.
On the skin of the feet, palms apply 0.25% cream amorolfine 1 time per day in the evening. Treatment is carried out continuously until healthy nails grow back. The duration of treatment depends on the degree and form of the lesion, the localization of mycosis and is
6 months for onychomycosis of the hands and 9-12 months for feet. Treatment on the skin is carried out until the resolution of clinical manifestations (at least 2-6 weeks) and a few more days after clinical recovery. Tolerance of varnish and cream is satisfactory, sometimes when applying varnish, a slight transient burning sensation in the nail area can be observed, and when using the cream, slight skin irritation (hyperemia, itching, burning sensation). Lacquer is contraindicated in case of hypersensitivity to it.
With the distal type of onychomycosis caused by dermatophytes, yeast-like and mold fungi, you can use 8% ciclopirox varnish in combination with 1% cream or 1% ciclopirox solution. Before applying varnish, most of the affected nail is removed with a file and filed to create an uneven surface. Lacquer is applied to the nail plate once a day with a thin layer. The nail polish layer is removed once a week with nail polish remover. Such treatment is carried out for 1 month. Then the varnish is applied to the nail plate 2 times a week for 1 month, starting from the 3rd month - 1 time per week. The duration of treatment depends on the form of the lesion, but should not exceed 6 months. Cream or solution of ciclopirox is applied to the skin 2 times a day (at least 2 weeks). After the resolution of clinical manifestations, the drug is used for another 1-2 weeks to prevent relapse.
In the distal type of onychomycosis, you can clean the infected part of the nail with bifonazole nail cream, and then rub a broad-spectrum antimycotic for external use 2 times a day into the nail bed or apply in the evening under an occlusive dressing (exoderil, econazole, ketoconazole, terbinafine, bifonazole, clotrimazole, etc.). At the same time, the treatment of smooth skin of the feet or hands is carried out until the resolution of clinical manifestations. The duration of treatment until the growth of healthy nails is from 6 to 12 months or more.
Based on many years of experience, we believe that the therapeutic effect in the treatment of onychomycosis will depend on right choice antifungal agent, taking into account the type, form of nail damage and the prevalence of the process, as well as regular disinfection of shoes (gloves) until healthy nails grow back.

Literature:

1. Stepanova Zh. V. Fungal diseases. -M.: Kron-Press. - 1996. - S. 176.
2. Stepanova Zh.V. - Doctor of Medicine. Sci., Leading Researcher, Mycology Group, Central Research Institute of Dermatovenerology, Ministry of Health of the Russian Federation, Moscow.

Onychomycosis is an infectious fungal disease of the nails. The disease can be caused by various pathogens, but in almost all cases, it manifests itself in the same way. Men suffer from onychomycosis more often than women.

With onychomycosis, the fungus invades the tissue of the nail plate and destroys it. thereby creating a nutrient medium for themselves. Not all fungi are capable of infecting nails. Most often, the causative agents of the disease are:

  • yeast fungi;
  • Dermatophytes;
  • Mold fungi.

Causes and symptoms of onychomycosis of the nails:

Fungus Causes and Contributing Factors

The disease has an infectious etiology, certain types of pathogens, and, therefore, its sources of infection. Most often, infection occurs:

  • By contact with infected people. Most of the fungi that cause onychomycosis belong to the category of anthroponotic infections that affect only humans. In this case, the cause of infection can be the use of shared towels, nail scissors, washcloths, removable shoes, slippers. Spores of such fungi can be perfectly preserved in the soil, as in an incubator for a long time, so there is no need to walk barefoot on the ground.
  • By contact with animals that can act as carriers of the pathogen.
  • From environment. There are types of fungi (mainly mold groups) that do not require living organisms for life and development. They can get to humans from water, soil, infected plants.

The chances of a rapid development of the disease increase with some factors, for example:

  • With diabetes;
  • In old age;
  • With vascular diseases;
  • Weak immunity;
  • Mechanical injuries of nails or skin diseases;
  • With regular visits to swimming pools, saunas or baths.

Classification of nail fungus

Consider the types of fungus of the nail plate, depending on the pathogen. Most often it is dermatophytes.

Dermatophytes

This group of pathogens of onychomycosis includes fungi (80% -90% of diseases):

Dermatophytes are imperfect fungi that can infect the skin, hair and nails..

The disease occurs against the background of reduced immunity. In this case, the infection is transmitted through contact with infected people, animals, or through soil in which fungal spores can be stored for a long period.

In the process of growth, almost all fungi of this genus form mycelium (mycelium), which is attached to the nail, thereby causing its destruction.

yeast mushrooms

The causative agent of the disease is most often:

  • candida tropical;
  • Candida parapsilosis.

Yeast fungi of the genus Candida live on human skin and mucous membranes, and this is the norm..

In the event that the patient's immunity weakens, they begin to actively multiply, causing certain diseases, including onychomycosis.

For infection, contact with another person is not required.

This genus of fungi does not form mycelium, so the destruction of the nail plate is rare.

mold mushrooms

Most often, from mold fungi, onychomycosis is caused by:

  • Asperqillus;
  • Fusarium;
  • Scopulariopsis brevicaulis.

More than 40 types of fungi can infect nails. They rarely become the cause of onychomycosis. The source of infection, in this case, is difficult to isolate, as well as to diagnose the disease.

There are no typical symptoms that would distinguish nail infection with a mold fungus, so the disease can be determined only after testing. Since the treatment of onychomycosis of the nails differs from that prescribed for the disease caused by dermatophytes, patients (often unsuccessfully) try to get rid of the disease.

Mold fungi quickly destroy the nail, can spread throughout the body and damage internal organs.

Types of onychomycosis

Forms and features of nail lesions

Distral-lateral form

The causative agent of this form of the disease, in more than 80% of cases, is the fungus Trichophyton rubrum, which often affects the nails on the lower extremities. This form of the disease is initial stage and indicates that the infection has occurred recently.

The nail plate is affected from the free edge or from the side surfaces.

Narrow gray-yellow stripes form on it, forming a zone of dystrophy, which gradually spread to the base of the nail. She becomes brittle and exfoliates.

With the progression of the disease: the nail thickens, exfoliates and can acquire different shades (from brown to dirty brown).

Much less often, the causative agents of this form of onychomycosis are yeast fungi (Candida albicans) and mold fungi (Scopulariopsis brevicaulis).

white surface mold

This form of onychomycosis is less common than the previous one. Almost always, the causative agent is Trichophyton mentagrophytes, and only in isolated cases, the mold Asperqillus can become the cause.

Small islands appear on the surface of the nail plate white color, which gradually merge and capture the entire area of ​​​​the nail. It starts to crumble () and takes on a gray tint.

The nail bed is not affected and the skin surrounding the nail is not inflamed. The disease mainly affects elderly patients.

proximal form

This type of disease is rare. The causative agent can be both dermatophytes and mold or yeast fungi. It occurs when the infection passes from the periungual roller or skin.

This article is often read:

The color of the nails changes, spots appear in the area of ​​\u200b\u200bthe nail hole, and the nail quickly begins to flake off. In this case, a secondary infection (re-infection) joins.

The neglected form of the fungus is treated for a long time, you can read more.

Dystrophic form

It is a consequence of the lack of treatment of previous forms of the disease. The nail is completely affected.

The nail fold thickens, the plate itself is almost completely destroyed and can no longer grow normally, only its remnants are visible.

Treatment methods for onychomycosis

For the treatment of onychomycosis, the following methods are used:

Topical treatment of nail fungus

Such treatment is carried out mainly with the use of special ointments, creams and other preparations containing substances that effectively destroy fungi. Such funds can be used, both independently, in full courses, and as part of complex combination therapy.

The advantage here is that the components of the ointments are delivered immediately to the site of the lesion, due to which the treatment process is not only more efficient, but also faster. However, there is also a downside. Means, as a rule, cannot penetrate into the deep nail layers, providing only a superficial effect. Therefore, there is a high chance of recurrence with this treatment.

The most commonly used drugs for the treatment of nails with onychomycosis:

  • (Isoconazole) as a cream, () as creams or ointments, () as creams, ointments or special solutions. These drugs belong to the Azolov group. Their action is reduced to inhibition of the development of microorganisms, the destruction of their cells with the help of enzymatic effects. They should be applied 1-2 times a day.
  • cream (Terbinafine), (Naftifin) in the form of a cream or a special solution. Means belong to the group of allylamines and destroy the membranes of fungal cells, which leads to their destruction. Apply them twice a day.
  • , Cyclopyroxolamine and other derivatives of the well-known Hydrocortisone, which actively inhibit the development of fungi, gradually causing their death. Apply twice a day with obligatory drying after application.
  • Salicylic ointment 3%. The tool effectively destroys dead keratinocytes, depriving the pathogen of nutrition.

Internal treatment of onychomycosis

Otherwise, this type of therapy is called systemic, and it is carried out using special capsules and tablets, the active substance of which is absorbed into the blood through the intestinal wall. The advantage of such funds is that their components are able to accumulate in the affected nails, creating a prolonged action and reducing the likelihood of further relapse. But the effect of them comes more slowly than from local drugs.

Such means include:

Surgical intervention

Today, operations to remove affected nails are already very rare, thanks to the vast possibilities of modern medicine and the availability of a wide range of drugs and various therapy methods.

The main indication for surgery at present is only the situation when a bacterial infection is added to the fungal infection of the nails, which requires radical measures. Also, nail removal is carried out when no medical treatment has given the expected effect.

As a rule, a secondary infection complicating the condition joins when basic hygiene rules are not followed, the disease is neglected, or the platinum of the affected nail is severely destroyed. Unlike fungi, additional infections can affect different types tissues, which contributes to the appearance of an inflammatory process and suppuration.

In this case nail to be removed so that doctors have the opportunity to conduct a more thorough treatment of a bacterial infection and prevent its spread.

It is important to remember that even the removal of the affected plate does not eliminate onychomycosis, therefore, it is necessary to take special drugs in any case, as well as follow other recommendations of doctors.

Today, instead of surgery, doctors are increasingly resorting to the procedure of avulsion of the affected nail, if necessary, to remove it. For this, the element is treated with special preparations, for example, Nogtivit, which contributes to rapid layer-by-layer dying and does not cause pain.

Alternative treatment of nail fungus

Treatment of onychomycosis of the nails at home may be accompanied by the use of traditional medicine. Of course, such an ailment can be completely cured only with the help of serious drug therapy, but some folk remedies are quite capable of slowing down the development of fungi and the destruction of the nail caused by them.

Before using any remedy, you should consult with a dermatologist or trichologist. The doctor will identify the type of pathogen and select the most appropriate drugs for treatment.

Hygiene for nail fungus and lifestyle

To prevent the disease from spreading and infecting your family and friends, some simple rules must be observed:

  • No need to wear someone else's shoes, even for a simple fitting. Since particles of the pathogen may remain in it.
  • It is better to avoid visiting public pools, baths or saunas, but if you need to go there, you need to wear rubber slippers and stay in them all the time.
  • After a bath or shower, the feet must be wiped dry and immediately treated with special anti-fungal agents.
  • In a residential area, it is important to wear slippers, preferably closed, but not creating a greenhouse effect. They should be disinfected after each treatment of the feet.
  • Wash the things of an infected person separately from the rest, and put them on a personal shelf.
  • After washing a sick person, the bath or shower must not only be disinfected, but also treated with special solutions against fungi, working only with rubber gloves and shoes.
  • The room should be ventilated frequently and wet cleaned daily using disinfectants, removing all carpets from the floor.

It is important to remember that fungi do not react to temperature changes, they do not die even at + 100 ° C and at - 60 ° C, so clothes should be disinfected, not boiled.

Prevention of nail fungus

Now you know how to treat onychomycosis of the nails, but infection can be avoided. In order not to get such an infection, it is necessary to wear the right shoes. In summer, it should not be cramped and completely closed. In winter, you should not be in boots or boots for a long time. Shoes must be right size, comfortable and light, do not rub, do not squeeze the leg and do not form corns.

Socks, stockings or tights must be natural materials without synthetics to ensure normal air circulation and avoid sweating. It is important to remember that the alkaline environment created by perspiration is an ideal environment for the rapid development of such microorganisms.

It is important to follow some rules, for example:

Nail fungus is an unpleasant disease of an infectious nature. It causes not only aesthetic inconvenience, but can also lead to a variety of complications - from a secondary bacterial infection to the spread of the lesion to other parts of the body. Fortunately, traditional medicine knows many recipes for dealing with the disease, which sometimes turn out to be more effective than modern medications.

It is called a fungal infection of the nail and nail roller on the hands or feet. This disease is one of the most common dermatological problems worldwide. According to some reports, this problem occurs in 5 - 15% of the population. The incidence is slightly higher in men and increases sharply in old age ( after 60 years, onychomycosis occurs 3-4 times more often).

Fungal nail infections can be caused by various types microorganisms, but almost always has similar manifestations. The disease is contagious, so both dermatologists and infectious disease specialists are involved in its treatment. Concomitant systemic diseases and other factors contributing to infection play an important role in the development of the disease.

Isolated onychomycosis is rare. Most often, patients have a parallel skin lesion on the feet or hands. Due to the absence of severe symptoms and a serious threat to health or life, people usually do not go to a specialist for a thorough diagnosis and treatment for a long time. In this regard, onychomycosis is often referred to more as a cosmetic problem.

The structure of the nail

From the point of view of anatomy, nails are a derivative of the surface layer of the skin ( epidermis). They are located on the tips of the fingers and toes from the back. Nails do not have a pronounced physiological function, but some researchers point to their protective role. To a greater extent, they are necessary for various manipulations in everyday life.

In the structure of the nail, it is customary to distinguish two main parts:

  • Nail body. The body is the visible flat plate on the back of the finger. Normally, it has a shiny surface, has a fairly high strength and a certain elasticity. The front edge of the body is free. The lateral edges abut against the skin rollers, limiting the growth of the nail in width. The thickness of the body is a few millimeters and is determined mainly by genetic factors. It has a layered structure, in connection with which layer-by-layer destruction or exfoliation of the nail plate can be observed. Proximal edge of the body ( located at the base) connects to the root of the nail. The lower surface of the nail plate is firmly attached to the underlying tissues with the help of short ligaments. They firmly hold the nail in their bed.
  • nail root. The root or matrix is ​​the growth zone. It is located under the skin roller at the base ( cuticle) and contains specific epithelial cells. In most people, this zone is visible at the very edge in the form of a narrow white strip ( hole). The cells responsible for nail growth are called onychoblasts. They have the ability to quickly divide and form the actual plate of the body. As new cells are formed, the entire body of the nail is shifted to the edge of the finger.
From the point of view of the chemical structure, a special protein, keratin, predominates in the nails. It is responsible for the fibrous structure of the fabric and gives it higher strength. In humans, keratin is present in the surface layer of the epithelium of the skin and in the hair. In animals, the horns and some parts of the bird's beak are made of keratin. It is the amount of keratin in the nails that largely determines the strength of the nails as a whole. Like other proteins, it is produced by cells from the genetic information encoded in DNA. As a result, some people's nails may be more brittle, soft, or thin. Sometimes this is not a symptom of any pathology, but an individual feature.

In addition to keratin, nails contain a small amount of fat and water. This gives the fabric a specific sheen and a certain elasticity. From additional chemical elements calcium, phosphorus, zinc and chromium are present. All of them are important for the normal division of onychoblasts and tissue growth. With some disorders in the exchange of calcium and phosphorus, nail growth may slow down or stop altogether.

Nail growth is a physiological process and occurs at an average rate of 0.5 - 2 mm per week. At the same time, the nails of the hands grow almost twice as fast. Growth disorders are one of the signs of onychomycosis or other diseases. In general, nails can respond to many different pathological processes in the body, changing their shape, color or growth rate.

Fungi affecting the nails

Not all fungi can infect nails. Determination of a specific pathogen in a patient is of great importance for predicting the disease and prescribing effective treatment. This is due to the fact that different groups of pathogens are sensitive to different drugs.

From the point of view of epidemiology, each individual geographical area is characterized by its own types of fungi. However, there are a number of microorganisms that are found almost everywhere. Each of them has its own characteristics in the development of onychomycosis. Sometimes this helps to suspect the type of fungus even before the appointment of a special analysis.

The most common causative agents of onychomycosis are:

  • dermatophytes;
  • yeast mushrooms;
  • fungi.

Dermatophytes

Dermatophytes are a group of imperfect fungi that are capable of causing some skin, hair, and nail diseases. Basically, the development of these microorganisms occurs in conditions of a decrease in general or local immunity. Without this, in healthy people, onychomycosis caused by dermatophytes rarely appears. The source of infection in this case can be other people or animals, but the main reservoir is the soil. It can store fungal spores long years. Germination and active development of fungi occurs best on dead keratinocytes ( cells containing large amounts of keratin).

The most important types of dermatophytes that affect the nails are:

  • Trichophyton rubrum. This type usually affects the tips of the nails, after which the infection gradually spreads towards the root. It usually develops in parallel on several fingers of the same limb or on the fingers of different limbs. The toenails are most commonly affected in 65 - 70% of cases). At the same time, the nail looks thickened and coarsened, it can exfoliate. Upon careful examination of the skin of the finger, you can notice its dryness and peeling, which indicates a parallel infection of the epithelium.
  • Trichophyton mentagrophytes ( interdigitale) . At this type pathogen develops white superficial onychomycosis. The fungus loves moisture, so the risk of infection is increased when visiting baths, saunas and pools. A typical symptom is a focal lesion of the nails on the big toes. Fingernails are rarely affected. In almost all patients, a parallel skin lesion between the fingers can be found.
  • Other dermatophytes. In addition to the above two types, nails are sometimes affected by other fungi of this family - Trichophyton schoenleinii, Trichophyton violaceum, Epidermaphyton floccosum. Onychomycosis caused by these types of fungi occurs in less than 5% of cases. Basically, they develop against the background of severe concomitant diseases.
Almost all dermatophytes form mycelium during growth. It is like a common rhizome for all fungi in the colony. It is attached to the nail by hyphae - filamentous structures that grow into the body of the nail. Due to this, the gradual destruction of the tissue occurs.

yeast mushrooms

The most common causative agent of onychomycosis is yeast fungi of the genus Candida. They normally live on the surface of the skin and mucous membranes of humans. Thus, contact with other sick people is not necessary for the development of nail lesions. In conditions of reduced immunity, yeast fungi simply spread to the area of ​​\u200b\u200bthe nails. The peculiarity is that this genus does not form mycelium. In this regard, the direct surface of the nail plate is rarely affected. The typical onset of infection is at the proximal end of the nail ( from the root, under the skin roller). As the disease progresses, the surface film peels off, causing the plate to lose its luster. Statistically, onychomycosis caused by yeast fungi is found more often on the hands ( about 60% of the time). During the course of the disease, periods of subsidence are noted ( remissions) and exacerbations ( relapses).

The main pathogens from the genus Candida are the following fungi:

  • C. albicans;
  • C. tropicalis;
  • C. parapsilosis.

mold mushrooms

Onychomycosis can cause more than 40 different types of mold fungi. They are ubiquitous, so it is difficult to identify the primary source of infection for these microorganisms. Nail damage by this group of fungi is quite rare, but can cause serious difficulties in diagnosis and treatment. The fact is that mold fungi do not give typical symptoms. Without a special bacteriological analysis, according to clinical observations, it is very difficult to distinguish them from dermatophytes. At the same time, this group of fungi requires a different treatment. In this regard, patients with such onychomycosis are often treated for a long time and unsuccessfully until a correct diagnosis is made. Molds are mainly affected by toenails.

The most common causative agents of the disease are the following fungi from this group:

  • Scopulariopsis brevicaulis;
  • Aspergillus ( different kinds);
  • Alternaria;
  • Fusarium.
Molds can form hyphae and lead to rapid destruction of the nail. In addition, some of them pose a risk of further spread throughout the body with lesions internal organs. Most often, such complications occur in people with severely weakened immunity.

The prevalence of onychomycosis pathogens in Europe

The causative agent of the disease The frequency of damage to the toenails The frequency of damage to the nails of the hands
Dermatophytes of the genus Trichophyton 75 – 80% 30 – 40%
Yeast fungi of the genus Candida 8 – 10% 45 – 50%
Mold fungi of various types 10 – 15% 10 – 15%
Other fungal infections About 1% Less than 1%


In addition, studies have been conducted that have proven that onychomycosis can be caused by a combination of several types of pathogen. This greatly complicates the correct diagnosis and treatment, because after the isolation of one microorganism, doctors often stop searching. In practice, the most common combination of two types of dermatophytes. Other associations of pathogens are found very rarely. Cases of damage to the nails by a combination of three different fungi have also been proven.

How can you get infected with a fungus?

Onychomycosis is an infectious disease, which, as mentioned above, has its own pathogens. Like any other infection, fungi have their own sources and transmission mechanisms. Most often, the infection enters the body from the external environment, but fungus from the skin can also spread to the nails. In this case, we speak of autoinfection. This requires some kind of external stimulus ( for example, a sharp decrease in immunity or malnutrition of the nail).

For causative agents of onychomycosis, the following sources of infection are characteristic:

  • Other people. Many fungi belong to the category of anthroponotic infections, that is, they affect only humans. In this case, infection occurs through household items from a sick person or carrier. Fungal spores get on washcloths, towels, removable shoes, nail scissors and thus infect healthy nails. The natural reservoir for such infections is the soil, where fungi can survive as spores for months or even years.
  • Animals. Some types of animals can be carriers of a fungal infection. A person becomes infected, as a rule, through contact with domestic animals. Onychomycosis caused by these types of pathogens are more common in tropical countries.
  • Environment. Some types of fungi can reproduce without the participation of living organisms. Then infection occurs upon contact with water, plants or soil in which microorganisms were located. This is especially true for pathogens from the group of mold fungi.
Based on this, it can be concluded that fungal infections do not have specific sources. It is very difficult to protect yourself from them, since these microorganisms are ubiquitous. This explains the high incidence of onychomycosis, which is recorded worldwide.

Fortunately, the variety of sources of fungal infection is offset by low infectivity. Each person comes into contact during his life with a huge number of infectious agents, but not every contact ends with the development of onychomycosis. This is due to the high efficiency of immune protection against fungal infection. Thus, in the process of infection, not only contact with the microorganism plays a role, but also the state of human health. For completely healthy people, the risk of fungal infection is very small. In this regard, it is necessary to know some factors that increase the likelihood of the disease. Their identification helps in the treatment of the disease and its prevention.

There are the following risk factors that increase the risk of infection:

  • elderly age;
  • mechanical damage to nails;
  • fungal skin infection;
  • weakening of the immune system;
  • frequent visits to public baths and saunas.

Elderly age

Statistically, onychomycosis occurs in the elderly several times more often than in children or middle-aged people. At the same time, a small predisposition to the disease in males remains.

The likelihood of fungal infection of the nails in older people increases for the following reasons:

  • Slowdown of metabolic processes. It's no secret that in old age the metabolism in the whole body is slowed down. This is reflected in the process of nail growth. In particular, due to digestive problems, there may be a lack of certain chemical elements or vitaminsnecessary for the normal formation of the nail plate. Against the background of growth disorders, fungi multiply more easily and colonize tissues faster.
  • Deterioration of blood circulation. With age, many people experience circulatory disorders. This is especially pronounced in the capillaries at the fingertips, which sometimes completely overgrow. Contribute to this process and common in old age problems with the cardiovascular system. The deterioration of blood circulation leads to oxygen starvation of tissues. This prevents the body from fighting the reproduction of fungi.
  • Late diagnosis. Older people are often less concerned about their appearance and are more prone to illness. Cosmetic defects in onychomycosis bother them less than young people. In this regard, the doctor is treated already in the later stages of the disease.
  • Non-compliance with personal hygiene. In old age, many people find it difficult to care for themselves due to other diseases. Because of this, older people are less likely to perform thorough hygienic cleaning of the nails and nail bed. This gives the fungi time to develop and colonize the nail plates.

Diabetes

One of the most common complications of diabetes is damage to small vessels. Most often this concerns the capillary network on the legs. Deterioration of blood supply and metabolism in such people leads to the appearance of diabetic foot. The tissues begin to gradually die off, and ulcers appear on the skin. One of the first signs of this complication can be onychomycosis. In this case, the fungus often affects not only the nails, but also the skin of the feet ( especially interdigital spaces and skin folds). The intensity of the fungal infection directly depends on the level of sugar in the blood. A course of treatment for diabetes in such cases will slow down the process and eliminate the fungal infection.

Mechanical damage to nails

Mechanical damage to the nails occurs in almost every person. This may be excessively deep cutting, breaking off or a crack in the nail plate. The problem is that the injury stops or impairs the supply of nutrients to a certain area of ​​​​the nail. This creates a favorable environment for the reproduction of fungi. From such a focus, the infection can subsequently spread to healthy tissues.

Vascular diseases

There are a number of systemic diseases in which damage to the vascular walls can be observed. First of all, these are rheumatological pathologies ( scleroderma, systemic lupus erythematosus, etc.). Small vessels on the arms and legs become overgrown, and blood circulation, accordingly, deteriorates. This process is especially pronounced in people with Raynaud's syndromewhen the blood supply deteriorates due to spasm of small vessels.

Deep vein thrombosis or varicose veins in the legs can also predispose to fungal infections. With these pathologies, there is a slowdown in blood circulation and stagnation of blood in the tissues. This disrupts metabolism and lowers the body's ability to resist infection.

Fungal infection of the skin

In people with fungal infections of the hands and feet, the chance of infection of the nails increases many times over. The fact is that most types of fungi equally easily affect the skin and nails. It is almost impossible to avoid infection in neighboring areas. Often, with mycoses of the skin, itching is observed. Scratching the affected areas automatically leads to the entry of the fungus under the nails. Over time, this leads to the development of onychomycosis.

Weakened immunity

The deterioration of blood circulation and metabolism leads to a weakening of local immunity. However, with some diseases, a serious weakening of general immunity can also be observed. First of all, we are talking about HIV ( AIDS virus). The body gradually loses its ability to resist any infection. Serious fungal infections of the skin and nails occur in more than 80% of HIV-infected people. In these cases, the disease will develop actively with the involvement of more and more new tissue areas and severe deformation of the nail plates. Standard treatment antifungal drugs while being ineffective.

In addition to HIV, long-term severe infectious diseases can lead to weakened immunity. At the same time, the course of antibiotic therapy exacerbates the situation, because fungi are not sensitive to antibiotics. Their growth against this background can only intensify. Somewhat less frequently, a rapid development of a fungal infection is observed after a course of treatment with corticosteroid drugs, cytostatics, or antidepressants. Weakening of the immune system is a side effect of these drugs.

Frequent visits to public baths and saunas

Frequent visits to baths and saunas simply increase the risk of infection. In most cases, the fungus gets on the nails during water procedures. Of course, sharing towels or washcloths increases the risk even more.

Mechanism of fungal infection of the nail

When fungi get on a healthy nail, the disease develops very slowly. Without malnutrition of the nail plate and in the normal state of the immune system, most pathogens will not be able to start tissue colonization. However, if the above risk factors are present, the development of the disease begins. Fungal infection is fixed on a certain part of the nail plate ( usually on the free or lateral edge) and gradually destroys the weakened nail. The main source of "nutrition" in this case are dead keratinocytes.


As they grow, some fungi create mycelium. It helps them attach to the nail plate. In parallel, air cavities are created in the thickness of the nail. Because of this, the tissue exfoliates or collapses. With the help of hyphae, the fungus attaches well to the surface of the nail and begins to grow into it. The defect can increase over time both in width and in depth. Mechanical cleaning of the nail or removal of the surface layer at this stage no longer gives anything, since the deep layers of the nail plate are also affected.

If the infection reaches the matrix, the formation of nail tissue may be disrupted. Onychoblasts cease to synthesize chemical substances necessary for normal nail growth. In this regard, growth may stop or the newly formed areas will be defective. All this only aggravates the course of the disease, contributing to the development of fungi. Thus, it is better to start treatment as early as possible, while the growth zone is not yet infected.

According to the mechanism of damage to the nail, the following forms of onychomycosis are distinguished:

  • distal-lateral subungual form;
  • surface white form;
  • proximal subungual form;
  • total dystrophy.

Distal-lateral subungual form

This form of the disease usually indicates a recent infection and is recognized by many experts as the initial stage of the process. In most patients without qualified treatment, onychomycosis passes into other forms. At first, there is usually a lesion of the free ( distal) the edges of the nail plate or its lateral edges.

In almost 85% of cases, this type of onychomycosis is caused by the pathogen Trichophyton rubrum, which has fallen under the edge of the nail from the surface of the skin. At first, narrow yellow-gray stripes may be observed along the edge of the nail plate. After that, the edge becomes more brittle and a clear zone of dystrophy appears. It differs in color from other areas of the nail and slowly moves towards the matrix. As you advance, delamination of the plate may be observed.

Surface white mold

This form is more common when nails are affected by mold fungi or Trichophyton mentagrophytes. Damage zones appear in the form of spots on the surface of the nail plate. Because of this, the white surface form is most clearly visible on the thumbs and toes. The affected area differs in color from the surrounding nail ( usually lighter, often white). When the edge of the plate or matrix is ​​reached, no further spread occurs. In the classical course, the defects tend to deepen into the thickness of the nail plate without signs of damage to the surrounding skin. Such meager symptoms often lead to the fact that patients do not go to the doctor for a long time.

The superficial white form is often found in people who work a lot with water or in a humid environment. At the same time, the nail plate becomes softer, which contributes to the appearance of defects in the form of spots. Sometimes this type of onychomycosis is observed after the end of the course of treatment of the fungus, when the pathogen has not been completely destroyed.

Proximal subungual form

This form is the most rare in medical practice. With it, the lesion occurs from the side of the nail roller above the root of the nail. The causative agent in proximal onychomycosis is usually fungi from the Candida family, which can enter the matrix area from the surrounding skin.

A distinctive feature of this form is a thickening of the nail at its base and a change in the color of the hole, while the plate itself ( body) remains unchanged for some time. Due to root damage, nail growth is quickly disrupted. As the disease progresses, a gradual detachment of the entire plate begins ( even if there are no signs of infection on it).

Total dystrophy

Total dystrophy is the most serious form of fungal infection of the nail. It can develop from the above forms in the absence of qualified treatment. Typical for it is focal or widespread destruction of the nail. It may be preceded by a gradual thinning of the body or a change in its color. Before this stage, the disease usually develops over the years. A rapid transition from distal-lateral subungual onychomycosis to total dystrophy usually indicates the presence of systemic diseases that exacerbate the course of the disease. This form is more common in the elderly. IN childhood such cases are extremely rare.

Regardless of the form of damage to the nail and its intensity, it is necessary to consult a doctor, because onychomycosis never goes away on its own. Having multiplied and invaded the nail plate, the fungal infection becomes very stable. The usual strengthening of the immune system will no longer return the nails to their former appearance. The process can stop, slow down or progress, but will not go back. Under the influence of the correct course of treatment, the fungus will die, and the mechanisms of nail growth will return to normal. As a result of this, the nail will regain its former appearance only after it grows back, when the nail plate is completely renewed.

Symptoms of onychomycosis

Symptoms of onychomycosis are in many ways similar to those of other nail diseases. In this regard, it is almost impossible to make a diagnosis only by external signs. However, there are typical local changes that should indicate to the patient the need for consultation with a specialist. One of the most typical and common symptoms of onychomycosis is a change in the thickness and shape of the body of the nail.


Changes in the thickness of the nail plate can occur as follows:
  • Hypertrophy. At the same time, the nail thickens and, as it were, rises from its bed. Thickening is usually uneven on the thumbs and uniform on the little fingers ( due to the small area of ​​the nail).
  • Atrophy. Atrophy indicates a serious malnutrition of the nail and is characterized by its thinning.
If there is no visible change in the thickness of the nail, they speak of normotrophic changes. They are observed in the early stages of the disease. In this case, the symptoms of the disease can be extremely diverse.

The main symptoms of onychomycosis


Symptom Typical type of lesion Short description Image (example)
Changing the color of the nail Total dystrophy The color is changed evenly, without pronounced spots. There is a lesion of the entire surface of the plate, often with growth disorders. The color depends on the type of pathogen.

Roughness of the nail surface Surface white mold Roughness is determined visually and by touch. It occurs due to the surface destruction of the plate and the gradual deepening of defects.

Dissection of the nail plate The delamination starts from the free edge of the nail and occurs gradually. The area of ​​delamination may increase over time.

White spots under the nail plate Proximal subungual form Such spots can be caused by detachment of the nail at its base. In the process of growth, a cavity is formed between the plate and the underlying tissue, which looks like a white spot.

Nail loss (dullness) Present in various forms of fungal infection The surface of the nail plate loses its luster gradually. There are no visible defects on its surface. There is a detachment of the uppermost thin layer ( skins) containing fat and water.

Increased burr formation Distal-lateral subungual form The causative agent of the disease also affects the skin roller around the nail. In this case, there is a faster necrosis of the skin along the edge of the nail, which begins to move away in the form of white or yellowish burrs.

Detachment of the nail plate Proximal subungual form, less often - total dystrophy Occurs due to violations in the growth zone. In this case, the plate may not change color much. Detachment occurs evenly, starts from the root of the nail and spreads as it grows.

Peeling of the skin of the feet and hands With concomitant fungal skin lesions The epidermis contains a layer containing significant amount keratin. Some types of fungi can affect it at the same time as the nails. The skin peels off in the form of small scales.

Pronounced destruction of the nail (onycholysis) Total dystrophy The nail plate is destroyed due to the germination of the fungal colony in its thickness while simultaneously affecting the growth zone. It occurs sooner or later in almost all patients without specific treatment onychomycosis.

Crumbs on the surface of the nail Surface white mold The fungus destroys the surface of the nail plate, because of which it begins to crumble. Over time, small defects in the form of depressions appear.


The appearance of any of these symptoms should be a reason for a visit to a specialist. Starting treatment with antifungal drugs at home without a confirmed diagnosis is fraught with aggravation of the pathological process and serious side effects.

Diagnosis of the cause of onychomycosis

Diagnosis of onychomycosis is aimed at establishing the causative agent of the disease. It usually presents significant difficulties, since it is difficult to suspect any particular microorganism by visible symptoms and manifestations. Without specific analyzes, sometimes it is not even possible to determine exactly whether there is a fungal infection of the nail, or whether all the changes are just a consequence of a metabolic disorder or other systemic diseases.

Diagnosis of onychomycosis goes through several stages and includes the following research methods:

  • clinical data;
  • microscopic examination;
  • cultural research;
  • DNA diagnostics.

Clinical Data

Clinical data is a collection of symptoms and complaints of the patient. In onychomycosis, they usually relate to external changes in the nail plates and associated skin symptoms. As noted above, the symptoms of onychomycosis are not specific to this disease. They only indicate the fact of damage to the nails. Finally, the cause of the disease can be established only after more accurate analyzes.

According to the results of clinical data, the doctor has to exclude the following diseases with similar manifestations:

  • psoriasis ( in case it affects the nails);
  • keratoderma;
  • malnutrition of the nails lack of vitamins or nutrients caused by other diseases).

microscopic examination

For microscopic examination, the specialist takes a scraping or tissue sample of the nail plate. The resulting material is treated with a special substance ( usually, a solution of KOH 10 - 30%) to break down keratin. After that, it becomes possible to examine the mushrooms under a microscope. An experienced doctor can distinguish the signs of a fungal infection of the nails with high accuracy. Unfortunately, this method does not allow you to determine the type of fungus and choose an effective treatment. However, if further investigations are not possible, a broad-spectrum antifungal agent can be given at this stage ( effective against various types of fungi).

Cultural study

Cultural examination is the third stage in the diagnosis and is carried out after microscopy. The material obtained from the patient is inoculated on a special nutrient medium ( Wednesday Saburo). It contains all the necessary substances for the rapid development of the fungus. Unfortunately, this type of microorganism grows relatively slowly. The results of the study are obtained on average 3 to 5 days after sowing.

Identification of the pathogen is carried out by the shape of the colonies, their color and the nature of growth. This method allows you to make an accurate and definitive diagnosis. An additional advantage is the ability to test the sensitivity of fungi to various drugs. Based on this study, the most effective course of treatment can be prescribed.

DNA diagnostics

A method is currently being sought to diagnose a fungal infection by detecting its DNA. In this case, the test material is also a scraping or a sample of nail tissue, which presumably contains the pathogen. On this moment The greatest success has been achieved in the diagnosis of dermatophytes and yeast fungi. Mold fungi are still difficult to identify in this way. The advantage of this method is the high accuracy and speed of the study. The result can be obtained within 1 - 2 days. The downside is the relatively low prevalence and the need for special equipment ( which increases the cost of analysis).

Treatment of onychomycosis

There are many different treatment regimens for onychomycosis. Their main task is to quickly and effectively destroy the fungal infection. A dermatologist will help determine the method of treatment, the choice of the drug and its dosage. Often, beauty parlors are also involved in the treatment of onychomycosis.

Hospitalization for this disease is not required. The patient can periodically visit a specialist and independently carry out all his instructions at home. In parallel with treatment, it is important to follow the principles of relapse prevention.


The total duration of the course of treatment largely depends on the form of damage to the nail and the type of pathogen. In the absence of aggravating factors, a slowdown in the process and positive dynamics can be observed within a few weeks after the start of treatment. To stop the course, it is desirable to undergo additional examinations in order to minimize the likelihood of recurrence of the disease.

In the treatment of onychomycosis, the following methods are used:

  • local drug treatment;
  • systemic drug treatment;
  • nail removal;
  • physiotherapy procedures;
  • treatment folk remedies;
  • treatment of comorbidities.

Local drug treatment

Local drug treatment is carried out mainly with the help of various creams and ointments containing antifungal drugs. Their appointment can be an independent course of treatment or be combined ( along with taking pills). The main advantage of local therapy is the direct delivery of the drug to the site of the fungal infection. This gives a more pronounced and faster effect. At the same time, creams and ointments do not penetrate deep into the thickness of the nail, so after such a course of treatment, the risk of recurrence of the disease is increased.

Indications for the appointment of only local treatment are:

  • the process affects less than half of one nail;
  • pinpoint lesions on several nails;
  • distal-lateral form of nail lesion;
  • lack of pronounced changes in the shape of the nail;
  • the presence of contraindications to the systemic administration of drugs.
Local treatment, in turn, has almost no contraindications, because the active components of the drugs do not enter the bloodstream. This minimizes the frequency of adverse reactions and complications and makes it possible to extend the course of treatment as needed.

The main drugs for the local treatment of onychomycosis

Drug group Name of the drug, analogues on the market Mechanism of action Receive mode
Azoles Ketoconazole (Nizoral), cream/ointment The drugs act on the enzyme system of fungi, slowing down their growth and leading to the gradual destruction of cells. 1 - 2 times / day.
Isoconazole (travogen), cream 1 time / day
Clotrimazole (candide), ointment/cream/solution 2 times/day
Allylamines Terbinafine (Lamisil), cream The drugs disrupt the normal functioning of the cell membrane of the fungus, which gradually leads to its death. 2 times/day
Naftifine (exoderil), cream/solution 2 times/day
Hydroxypyridone derivatives Cyclopyroxolamine (batrafen), cream/nail polish Suppresses the reproduction of most fungi, slowing down their growth and development. Over time, microorganisms die. 2 times / day, the nail after applying the cream should be dried.
Keratolytic agents 10% sulfur, 3% salicylic ointment Promotes the destruction of dead keratinocytes, which deprives fungi of nutrition. By doctor's prescription.
Halogen-containing preparations Alcohol tincture of iodine 2% Prevents the attachment of a bacterial infection, dries the affected area, slows down the growth of the fungus. In the form of compresses or lotions 1 - 2 times / day.

Systemic drug treatment

Systemic drug treatment involves taking drugs in the form of tablets and capsules. In this case, the medicinal substance is absorbed in the intestines and enters the bloodstream. Most modern drugs used in the treatment of onychomycosis tend to accumulate in the nails. This gives a more pronounced and lasting therapeutic effect. However, visible improvements come later than in the case of ointments and creams. The likelihood of relapse with a fully completed course of treatment is relatively small.

Unambiguous indications for the appointment of systemic or combined treatment are the following indicators:

  • severe damage to the entire nail plate;
  • involvement of the nail root in the pathological process;
  • destruction of the nail;
  • a combination of several types of fungi;
  • parallel damage to the skin or other areas of the body;
  • lack of effect after a course of local therapy.
Most antifungal drugs have severe side effects, which are especially strong in case of long-term use. In this regard, the selection of the drug and the mode of its administration are prescribed only by the attending physician after a thorough examination of the patient. His decision will be influenced not only by the sensitivity of the fungi themselves to the drug, but also by how the patient tolerates the treatment.

Drugs used to treat onychomycosis

Name of the drug The mechanism of action and features of the drug Dose and regimen
Griseofulvin Suppresses protein synthesis in fungi. This leads to a quick stop of their division and destruction. The standard dose is 500 mg / day, the maximum is 1 g. The dose can be divided into 2-3 doses. It is desirable to take during meals or immediately after it. The course of treatment is from 3 to 6 months.
Ketoconazole Blocks biochemical processes in the metabolic chains of fungi. Has a pronounced hepatotoxic ( damages the liver) and antiandrogenic ( blocks the action of male sex hormones) action. 200 mg per day. Long-term treatment is contraindicated due to side effects.
Itraconazole The mechanism of action is similar to that of ketoconazole. 200 mg 2 times a day for a week once a month. With damage to the nails on the hands, 2 sessions are prescribed, with damage to the nails on the legs - 4.
Fluconazole The mechanism of action is similar to that of ketoconazole. It is especially active against yeast fungi of the genus Candida. 150 - 400 mg once a week. The course of treatment lasts up to 24 weeks.
Terbinafine Active against all types of fungi. Destroys cell membranes, leading to the destruction of microorganisms. 250 mg per day. With damage to the hands, the course of treatment is 6 weeks, with damage to the legs - 12.

The table shows the doses and regimen for adults. With onychomycosis in children, many of the above drugs will be contraindicated, or their dose will be greatly reduced. In this regard, self-treatment of children with antifungal drugs is prohibited due to severe side effects.

Nail removal

Currently, the surgical removal of nails affected by the fungus is almost not practiced. The main indication for this is the addition of a bacterial infection or the complete absence of the effect of drug treatment ( resistant forms of fungus). Accession of a secondary infection occurs quite often with advanced onychomycosis, severe destruction of the nail plate and non-compliance with personal hygiene. If the fungal infection is usually limited to the nails and the surface of the skin, then the bacteria can also infect neighboring tissues. This leads to the formation of pus, its accumulation and the development of a serious inflammatory process. In such cases, the nail is recommended to be removed for a more thorough treatment of a bacterial infection. It should be understood that even removing the nail is not a radical solution to the problem of onychomycosis. Regardless of this, antifungal medication should be continued, as the infection is still present in the body and there is a risk of other nails being affected.

An alternative to surgical intervention is the artificial "dissolution" of the affected nail ( avulsion). There are a number of drugs nails and its analogues), which contribute to the rapid keratinization of nails and their layer-by-layer death. This method is now widely practiced because of the painlessness and the possibility of performing at home. However, it should only be used after consulting a dermatologist.

Physiotherapy methods

Currently, the high efficiency of laser treatment of onychomycosis has been proven. The affected nail is irradiated with a laser with adjustable radiation intensity. It penetrates into the thickness of tissues and causes local destruction of the fungus. In fact, laser treatment is an alternative to local drug treatment because it has the same effect. It can be prescribed for intolerance to antifungal ointments or creams.

Laser treatment of onychomycosis is painless and has no side effects. However, it does not have a comprehensive effect and reduces the risk of recurrence of the disease. In this regard, it is recommended to combine laser treatment with systemic antifungal drugs.

Treatment with folk remedies

As mentioned above, a complete cure for onychomycosis is possible only with the help of drugs with a strong antifungal effect. However, some traditional medicine recipes can help slow down the destruction of the nail plate or even stop the process for a while. Many doctors even endorse the use of these drugs after a course of treatment in order to prevent relapses.

To prevent the recurrence of onychomycosis, it is recommended to use the following folk methods treatment:

  • Alcoholic infusion of garlic. Grated heads of garlic are poured with medical alcohol in a ratio of 1 to 10. Infusion lasts at least 2-3 days in a place protected from direct sunlight. The resulting infusion lubricates the affected nails 1-2 times a day. It is advisable to avoid getting the product on the skin roller.
  • Garlic compress. Grated heads of garlic are mixed with boiled water in a ratio of 1 to 2. The resulting mixture is well shaken and filtered. A cotton swab or bandage is soaked in the resulting liquid, and tied to the affected nail for 20 to 30 minutes. The procedure should be repeated daily.
  • Peppermint with salt. Crushed peppermint leaves are mixed with water in a ratio of 1 to 1. Salt is added to the resulting mixture ( one teaspoon per glass of liquid). With this tool, you can treat not only the affected nail plates, but also the skin of the fingers, if it also has signs of a fungal infection.
  • Alcoholic infusion of lilac. For 10 g of fresh lilac flowers, take half a glass of medical alcohol. Infusion lasts 6 - 8 days. The resulting agent is used to treat growing healthy nails after a course of treatment with antifungal drugs.
  • Infusion of celandine. For 200 g of dry leaves of celandine, 1 - 2 liters of boiling water will be required. The mixture is infused as it cools. In this case, it can be slowly stirred. When room temperature is reached, hand and foot baths are made in the resulting liquid. The duration of the procedure is 5 - 10 minutes.
  • Baths with a row. Half a liter of boiled water will require 30 - 40 g of grass. The mixture is brought to a boil and simmered for 20 minutes. In the resulting broth, baths for hands and feet are made for 15 to 20 minutes.

Treatment of comorbidities

As noted above, fungal infections of the nails develop especially intensively with serious concomitant pathologies. Against the background of these diseases, treatment with antifungal drugs may not give the desired effect. In this regard, special attention should be paid to the treatment of comorbidities.

The main measures for concomitant diseases are:

  • Vitamin therapy for chronic diseases of the gastrointestinal tract (gastrointestinal tract). If the body does not absorb nutrients, you can periodically enter them in the form of injections bypassing the digestive system.
  • Maintaining a high level of leukocytes in HIV infection. This is possible through regular intake of antiretroviral drugs. Intensive treatment will delay the incurable disease by 1-2 stages and allow the fungus to be cured.
  • Maintaining normal pressure in diseases of the cardiovascular system. This will ensure normal blood circulation in the fingertips and help fight the fungus.
  • Maintaining normal glucose levels in diabetes mellitus. Prolonged and high blood sugar levels lead to irreversible changes in the nerve endings and vessels of the feet. Compliance with all recommendations for diabetics and the necessary course of treatment will help stop dystrophic processes and increase the effectiveness of the course of antifungal drugs.
  • In Raynaud's syndrome, hypothermia should be avoided, which most often leads to spasm of small vessels. This will ensure normal blood flow in the fingers and improve the metabolic processes in the nails.
After the end of the course of treatment, it is necessary to visit a dermatologist again. Only a specialist will be able to assess how successful the treatment was and whether it should be stopped. There are no single criteria by which the patient could navigate independently. The doctor will take a scraping or swab from the nail and conduct an appropriate analysis. Negative result is sufficient evidence to stop treatment. In this case, the nail itself can still be destroyed. The cosmetic defect will disappear as the nail plate grows in about a few months, if the growth zone has not been damaged.

Prevention of onychomycosis

Prevention of onychomycosis is divided into primary and secondary. Primary prevention is aimed at eliminating factors that increase the risk of developing a fungal infection. Secondary prevention is important for people who have already been diagnosed with onychomycosis and have completed a full course of treatment. In such cases, it is important to prevent the recurrence of the disease and give the body time to completely renew the nail plate.

To prevent onychomycosis, the following rules must be observed:

  • use of own shoes and personal hygiene products both in public pools and at home;
  • strengthening general immunity;
  • prophylactic use of antifungal drugs during long courses of antibiotic therapy;
  • regular cleaning of the nail bed and personal hygiene;
  • washing hands and feet with soap after swimming in open water or contact with soil;
  • washing hands after contact with animals;
  • treatment of chronic diseases that increase the risk of developing onychomycosis;
  • regular change of socks and airing shoes.
Separately, you should consider the issue of disinfection of shoes during the course of treatment. The fact is that it is in it that fungi usually hide, which in the future lead to a relapse of the disease. To eliminate them, strong chemical disinfectants are used. The procedure should be repeated at least once a week. With onychomycosis on the nails of the hands, the patient's gloves are treated in the same way. After the start of treatment, it is recommended to completely change socks for new clean pairs. The washcloth and towels can also be replaced, and the manicure and pedicure set must be sterilized.

To disinfect shoes and clothes, you can use the following drugs:

  • solution of chlorhexidine bigluconate 1%;
  • formalin solution 25%;
  • acetic acid 40%;
  • other branded shoe care products.
In addition, special devices for drying shoes have been developed for preventive purposes. Since most fungi prefer a moist environment, the use of such devices will help get rid of the infection.

Only compliance preventive measures can lead to full recovery. Without it, any course of treatment with the most effective drugs will give only a temporary improvement, and over time, onychomycosis will develop again. Measures to disinfect shoes and gloves should be carried out until normal nail plates grow back during treatment. After that, it is recommended to consult a dermatologist. In most cases, the metabolism in the nails is completely restored, and in the future the body itself will be able to protect itself from the development of the disease.


Onychomycosis (nail fungus) - causes, types, symptoms, diagnosis, treatment and prevention

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Onychomycosis is a fungal infection of the nail plate, which can be caused by various types of pathogens. fungi. With onychomycosis, one or more nail plates on the hands, on the feet, or simultaneously on the fingers of the lower and upper limbs of a person can be affected. However clinical picture and the features of the course of infection are exactly the same, both on the nail plates of the fingers and feet. That is, onychomycosis of the nails of the hands does not differ from that of the toes.

However, there are various options the course of a fungal infection of the nails, which are determined only by the type of pathogen, the duration of the existence of the pathological process and the extent of the lesion of the nail plate. Onychomycosis in children, adults and the elderly are exactly the same diseases, differing from each other only in the speed of recovery.

Onychomycosis of the nails of the feet and hands - the frequency of occurrence and pathogens

According to international statistics, 10-20% of the total population of the Earth suffer from onychomycosis, and fungal infections account for at least 1/3 of all nail diseases. However, in the last decade, these figures have been revised, as practicing dermatologists note an increase in the number of patients seeking help for mycosis nails.

Unfortunately, clinical observations show that an increase in the frequency of onychomycosis is observed not only in adults, but also in children, which is due to infection in the family. In addition, the likelihood of developing an infection increases with age, especially in older people over 65 years of age, due to the presence of such chronic diseases as vascular pathology, obesity, osteoarthropathy of the feet, diabetes mellitus, etc.

Onychomycosis can be caused by the following types of pathogenic and opportunistic fungi:

  • Dermatophyte Trichophyton rubrum (is the causative agent of infection in 75 - 90% of cases);
  • Dermatophyte Trichophyton interdigitale (is the causative agent of infection in 10 - 20% of cases);
  • Trichophytes T. violaceum, T. tonsurans, T. schoenleinii, T. mentagrophytes var. gypseum, T. Verrucosum (are the causative agents of infection with 1 - 3% of cases);
  • Inguinal epidermophyton Epidermophyton floccosum;
  • The causative agent of microsporia Microsporum canis;
  • Yeast-like fungi of the genus Candida;
  • Molds of the genus Aspergillum.
In recent years, the number of cases of onychomycosis caused by molds or several types of fungi at the same time has increased. So, the combined damage of nail plates by dermatophytes and mold or yeast fungi is most often noted.

Onychomycosis in children

Onychomycosis in children does not differ from that in adults either in clinical course, or in symptoms, or in the features of damage to the nail plates of the feet or hands, or in any other parameters that are significant for diagnosis and treatment. Therefore, consideration of onychomycosis in children is inappropriate to single out in a separate article or section.

Causes and development of onychomycosis

The cause of the development of onychomycosis, like other infectious diseases, is a pathogenic microorganism, in this case, a fungus. The infection develops after the penetration of the fungus into the structures of the nail, where it begins to multiply and form tunnels and passages.

Infection with pathogenic fungi that cause onychomycosis, as a rule, occurs when visiting various public places in which people stand or walk barefoot for at least a certain amount of time, for example, baths, saunas, swimming pools, showers in large enterprises, gyms, etc. . Quite often there is a transmission of the causative agent of onychomycosis within the same family when using the same household items, such as washcloths, slippers, rugs, grills, gloves, etc.

Infection usually occurs as follows: flakes of skin and nails in people suffering from onychomycosis fall off and fall on rugs, bedding, washcloths, bath surfaces, carpets, towels and other objects. These scales contain fungal spores and mycelium that can persist for years. When another person steps on or touches a household item that has such scales, they stick to his skin, the fungus is activated and goes to the nails. Wooden objects are especially dangerous in terms of infection, since scales with fungi are almost impossible to wash and remove from the pores of the tree. Most often, fungi of the toenails are first infected, and the person himself transfers them to the nail plates of the hands.

The following factors contribute to infection with onychomycosis:

  • Nail injuries;
  • Various violations of the integrity of the skin of the feet and hands (cuts, scratches, abrasions, etc.);
  • Immunodeficiency states;
  • Wearing shoes that create the effect of a steam room;
  • Tight, uncomfortable shoes;
  • Reduced or increased sweating of the feet;
  • Non-observance of hygiene rules;
  • Diabetes;
  • Blood diseases;
  • Long-term use of antibiotics, glucocorticoids and cytostatics.
In the presence of predisposing factors, infection with onychomycosis occurs faster and easier compared to those people who do not have them.

Onychomycosis usually does not develop immediately, but after infection of the skin of the feet. Before the appearance of a characteristic lesion of a human nail, as a rule, peeling, cracks, maceration and blisters on the skin in the area of ​​interdigital folds, on the sole or on the palm of your hand are disturbing. Often this skin lesion is accompanied by itching. And only some time after the fungus affects the skin of the palms or feet, it passes to the nails. In rare cases, there is isolated onychomycosis, when the fungus immediately penetrates directly into the nail plate from under any of its edges.

Forms of onychomycosis (classification)

Currently, in the countries of the former USSR, two classifications of onychomycosis are used - the first is based on the type pathological changes in the nail plate, and the second - on the localization of the process.

Based on the type of prevailing pathological changes in the structure of the nail, all onychomycosis is divided into the following types:

  • Normotrophic;
  • Hypertrophic;
  • Atrophic (onycholytic).
Based on the localization of the fungal infection of the nail plate, the following forms of onychomycosis are distinguished:
  • Distal onychomycosis (only the free edge of the nail, which is usually cut off, is affected by the fungus);
  • Lateral onychomycosis (the fungus affects one or both sides of the nail, located next to the skin rollers);
  • Proximal (the fungus affects the posterior roller and the growth part of the nail at its very base);
  • Total (the entire surface of the nail plate is affected by the fungus);
  • White superficial onychomycosis (mycotic leukonychia), in which white spots appear on the nail.
Distal and lateral onychomycosis often co-occur, which is why some doctors and scientists combine them into one form, distal-lateral subungual onychomycosis.

Symptoms

Each form of onychomycosis is characterized by its own distinctive clinical symptoms, which we will consider separately.

Onychomycosis normotrophic

Normotrophic onychomycosis is characterized exclusively by a change in the color of the nail plate while maintaining normal thickness and luster. First, spots and stripes of various sizes and shapes appear, painted in white or ocher-yellow color on the lateral parts of the nail. As onychomycosis progresses, these spots and stripes increase in size, gradually covering the entire nail plate. As a result, the entire nail changes its color, while continuing to maintain its normal thickness and shine.

In normotrophic onychomycosis, the nail often does not adhere to the nail bed (onycholysis), so it can easily be accidentally or intentionally removed.

Onychomycosis hypertrophic

Hypertrophic onychomycosis is characterized by a change in the color of the nail and an ever-increasing thickness (more than 2 mm). The nail thickens due to subungual hyperkeratosis - increased formation of skin scales.

In hypertrophic onychomycosis, the affected nails lose their luster, become dull, thicken, crumble, and become severely deformed. The deformation of the nail is the stronger, the longer the disease proceeds. Quite often, people suffering from hypertrophic onychomycosis for a long time have onychogryphosis, which is a deformation of the nail in the form of a bird's claw.

The nail plates are gradually destroyed, especially in the lateral parts. Due to the deformation, thickening and destruction of the nail plates, quite often people feel pain when walking.

The nail is usually colored gray or dirty yellow.

Onychomycosis atrophic

Atrophic onychomycosis is characterized by a change in the normal color of the nail to brownish-gray. The nail plate loses its luster and becomes dull. Gradually, the nail collapses, decreases in size and completely atrophies, exposing the nail bed, on which loose layers of a large number of skin scales are visible. The nail plate changes gradually, the pathological process first covers the outer end, and as the infection progresses, it moves to the growth zone and skin fold. Moreover, the growth zone, even with the rest of the surface of the nail affected, remains unchanged for a very long time.

Distal and lateral (subungual) onychomycosis

Distal and lateral (subungual) onychomycosis are characterized by the same changes in different parts of the nail plate. In addition, very often distal and lateral onychomycosis are combined with each other.

The affected part of the nail becomes dull, mottled with transverse furrows and painted in a pale yellow hue. If onychomycosis is provoked by mold fungi, then the nail plate can be painted blue-green or black.

The nail crumbles, as a result of which its free end or side parts become rough. Gradually, the entire affected area is painted, and fragments of the nail fall off. As the infection progresses, other fragments of the nail are painted and fall off, as a result of which it acquires an irregular shape that does not completely cover the nail bed. Over time, the entire nail falls off and only the nail bed remains on the finger, covered with keratinized skin scales.

With lateral onychomycosis, the lateral folds of skin surrounding the nail become swollen, red, thickened, and painful. If a bacterial infection joins a fungal infection, then a small amount of pus may appear from under the rollers when pressed.

Proximal onychomycosis

Proximal onychomycosis is quite rare and is characterized by damage to the nail from the side of the skin roller in the region of the growth zone. This type of onychomycosis most often occurs when the eponychium is removed - a special layer of skin that is located between the nail plate and the posterior roller, and in everyday speech is called the cuticle.

Proximal onychomycosis begins with the formation white spot on the part of the nail adjacent to the growth zone. In this white spot, the fungus forms tunnels and passages in which its mycelium and spores are located. Gradually, the fungus penetrates the cells of the nail bed, as if surrounding the growing nail from all sides. This leads to the complete destruction of the entire nail that has not yet grown.

Total onychomycosis

Total onychomycosis is the final stage of the proximal, distal or lateral, as it is characterized by damage to the entire surface of the nail plate. Usually, a fungal infection begins with the defeat of a small area of ​​​​the nail and gradually spreads to the whole, forming a total onychomycosis.

The nail becomes dull, crumbling, exfoliating, deformed and colored in various shades of gray, white or dirty yellow.

White superficial onychomycosis

White superficial onychomycosis is characterized by the formation of opal-white spots in the region of the posterior ridge of the nail, which gradually spread to the entire surface of the nail plate. White spots merging with each other look like a scattered fine powder.

Diagnostics

Diagnosis of onychomycosis is based on examination of the nail, during which the doctor makes a preliminary diagnosis. Then, in order to confirm onychomycosis, a scraping is taken from the surface of the nail or a small affected piece is bitten off. The resulting material is examined under a microscope or sown on Sabouraud's medium. If spores and mycelium of the fungus are detected during microscopy or inoculation on the medium, then onychomycosis is considered confirmed. From this moment you can start treatment.

Onychomycosis - treatment

General principles of therapy

Modern effective treatment of onychomycosis consists of the simultaneous use of the following methods and drugs:
  • Taking systemic antifungal drugs;
  • Treatment of the affected areas of the nail and the surrounding skin with local antifungal agents, for example, ointments, gels, varnishes, etc.;
  • Removal of the nail plate by a surgical or conservative method with its total lesion and severe thickening;
  • Taking drugs that improve blood circulation to the peripheral tissues of the feet and hands;
  • Courses of physiotherapy, also aimed at improving blood flow in the feet and hands.
For effective and reliable treatment of onychomycosis, it is necessary to use systemic antifungal drugs that destroy the infectious agent. Since the fungus reproduces by spores, which can remain inactive for a long time in the growth zone of the nail, but are quite viable, it is necessary to achieve the destruction of these spores in order to completely cure the infection. Usually, as the nail plate grows, these spores rise and become active, causing an infectious process. That is why the therapy of onychomycosis with antifungal drugs is carried out for a long time - until a new and healthy nail plate fully grows, since this will mean that all the spores that remained in the growth zone have died.

In addition to systemic antifungal agents, it is highly recommended to use topical preparations that are applied directly to the nail plate. These antifungal agents contribute to the local destruction of spores and mycelium of the fungus in the scales of the nail, thereby preventing the spread of potential objects of re-infection. After all, if scales with fungi fall off the nail, they will remain in shoes, socks, carpets and other household items, which can easily lead to infection a second or even third time.

The use of systemic and local antifungal drugs for the treatment of onychomycosis is mandatory. Removal of the nail plate is not performed in all cases, but only when it is severely deformed and thickened, as a result of which it is impossible to destroy the fungus in all cells of the nail. The use of other drugs and physiotherapy is made at the request of the person.

During the entire period of therapy for onychomycosis, it is necessary to conduct a follow-up examination with a doctor once every two weeks. Six months after the end of therapy, it is necessary to do a scraping of the nail, followed by a microscopic examination. If microscopy reveals the mycelium of the fungus, then the course of treatment must be repeated.

Let us consider in more detail all types of necessary treatment of onychomycosis.

Removal of the nail plate conservatively

Removal of the nail plate is conservatively performed using keratolytic patches that soften the nail. After applying such a patch, the nail is removed easily and painlessly using ordinary scissors or a non-sharp scalpel.

Currently, the following keratolytic patches are used to remove the nail:

  • Onychoplast 30%;
  • Ureaplast 20%;
  • Salicylic-quinozole-dimexide patch;
  • Mycospor set.
These patches can be ordered at the prescription department or bought ready-made in pharmacies.

Before applying the composition to the nail, it is necessary to stick pieces of ordinary adhesive plaster on nearby healthy skin areas to protect them from the effects of keratolytic. Then the mass is applied to the nail with a layer of 1 - 2 mm, after which it is fixed with an ordinary adhesive plaster and left for 2 - 3 days. After that, the adhesive plaster is peeled off, the remnants of the mass are removed and the exfoliated areas of the nail are scraped off with a scalpel. Then, if necessary, the procedure is repeated until the entire nail is removed and only the nail bed remains.

After removing the nail, the exposed nail bed is treated with antifungal varnishes, for example, Batrafen, Loceryl, etc.

Removal of the nail plate surgically

Removal of the nail plate by a surgical method is preferable to a conservative one, since it allows not only to remove the affected nail, but also to clean the nail bed from a large number of keratinized scales of the epidermis (hyperkeratosis), which may contain cysts with numerous fungal spores. Clinical observations have shown that with surgical removal of the nail and subungual hyperkeratosis, the effectiveness of therapy is higher, and the risk of recurrence is significantly lower compared to the conservative method of removing the affected nail.

Surgical removal of the nail is performed as follows:
1. A tourniquet is applied to the base of the finger;
2. Treat the finger with any antiseptic;
3. A local anesthetic is injected into the lateral surfaces of the finger;
4. The tweezers are inserted under the free edge of the nail in the region of the right or left corner;
5. Move the tweezers to the base of the nail;
6. Separate the nail eversion movement in the direction from the corner to the center;
7. Remove the accumulation of horny scales on the nail bed;
8. Irrigate the nail bed with a sorbent powder with an antibiotic;
9. Apply a sterile bandage.

After a new epithelium forms on the nail bed, they begin to treat it with local antifungal agents - varnishes, ointments, lotions, etc.

Systemic treatment of onychomycosis

Systemic treatment of onychomycosis consists of oral antifungal drugs for 6 to 12 months. Currently, the following antifungal drugs are used to treat onychomycosis:
  • Griseofulvin;
  • Ketoconazole;
  • Itraconazole;
  • Terbinafine;
  • Fluconazole.
The list only lists the international names of the active substances (INN) in order to avoid long lists of drugs that contain exactly these active ingredients and are released under different commercial names.

Griseofulvin and Ketoconazole with onychomycosis of the feet should be taken for 9-18 months, and hands - 4-6 months. The use of these drugs provides a cure for onychomycosis in only 40% of patients. If the surgical removal of the nail plate is performed, then the percentage of cure increases to 55 - 60%.

Itraconazole is used according to two possible schemes - continuous administration and pulse therapy. With continuous use, the duration of therapy for onychomycosis of the nails of the hands is 3 months, and of the feet - 6 months. Pulse therapy is an alternation of doses of the drug during the week and breaks between them in three weeks. For the treatment of onychomycosis of the nails of the hands, two courses of pulse therapy are required, and of the feet - 3-4 courses. Complete cure even without conservative nail removal is observed in 80-85% of patients.

Terbinafine for the treatment of onychomycosis of the nails of the hands is taken for 1.5 months, and the feet - 3 months. Cure is observed in 88 - 94% of patients.

Fluconazole for the treatment of onychomycosis of the nails of the hands is taken for six months, and the feet - for 8-12 months. Cure is observed in 83 - 92% of patients.

Thus, it is obvious that the most effective drugs for the treatment of onychomycosis are Terbinafine, Itraconazole and Fluconazole.

Local treatment of onychomycosis

Topical treatment of onychomycosis should complement systemic therapy but should never replace it. It should be remembered that local treatment of onychomycosis will not achieve a complete cure if it is not combined with oral antifungal drugs in the form of tablets, capsules, solutions and other pharmaceutical forms, since fungal spores can remain in destroyed tissues for a long time in a viable state. The drugs for the local treatment of onychomycosis simply cannot penetrate into these destroyed tissues, since they are located in the cells of the nail bed, directly under the nail.

Local therapy of onychomycosis consists in treating the nail or nail bed with various preparations produced in the form of ointment, cream, varnish, lotion, spray, etc. Currently, effective local antifungal drugs that are indicated for use in the complex therapy of onychomycosis are the following:

  • Preparations containing clotrimazole (Amyclone, Imidil, Candibene, Canison, etc.);
  • Preparations containing miconazole (Daktarin, Mikozon);
  • Bifonazole preparations (Bifasam, Bifonazol, Bifosin, Mikospor);
  • Econazole preparations (Pevaril and others);
  • Isoconazole preparations (Travogen, Travocort);
  • Terbinafine preparations (Atifin, Binafin, Lamisil, Mikonorm, etc.);
  • Preparations of naftifine (Exoderil);
  • Amorolfine preparations (Loceryl);
  • Preparations of ciclopiroxolamine (Batrafen, Fongial).
Local therapy is carried out until a new healthy nail grows. In parallel with the application of topical antifungal drugs to the nails, it is necessary to take care of the nail plates, washing them daily with warm water and soap, cutting and filing.

Physiotherapy

With fungal infection of the nails, it is necessary to improve the microcirculation of blood in the toes and hands as much as possible, since this ensures the delivery of antifungal drugs in a therapeutic dosage and, accordingly, the destruction of the infectious agent. To improve microcirculation and accelerate the growth of a new healthy nail plate, the following physiotherapeutic procedures are indicated as part of the complex therapy of onychomycosis:
  • UHF therapy on the paravertebral regions in the lumbosacral and cervicothoracic regions for 7 to 10 days in a row;
  • Amplipulse therapy on the paravertebral regions in the lumbosacral and cervicothoracic regions for 7 to 10 days in a row;
  • Diathermy on the paravertebral regions in the lumbosacral region for 7-10 days in a row;
  • Supravascular laser irradiation of blood in the region of peripheral blood vessels. Irradiation is performed at a power of 15 to 60 mW for a duration of 6 to 10 minutes for each area.
Physiotherapy is an auxiliary component of the complex therapy of onychomycosis. During the course of treatment of onychomycosis, which is always long, you can alternately apply different methods of physiotherapy.

Preparations that improve blood circulation in the hands and feet for the treatment of onychomycosis

These drugs improve the blood supply to the fingers and toes, and, therefore, guarantee the delivery of the antifungal drug to the nails in the required concentration. Also, the intensification of blood flow contributes to the rapid growth of a new nail, which helps to somewhat reduce the duration of therapy.

For this purpose, it is advisable to use the following drugs:

  • Pentoxifylline (Trental, Agapurin, etc.) 400 mg 2-3 times a day;
  • Calcium dobesilate (Doxy-Hem, Doxium) 250-500 mg 3 times a day;
  • Nicotinic acid 150 - 300 mg 3 times a day or 15 injections of 1 ml of a 1% solution.
These circulatory drugs are also ancillary, and can be used in combination with antifungals, not instead of them.

Treatment regimen for onychomycosis

Treatment regimens for onychomycosis consist of the obligatory intake of an antifungal drug orally and topically applied to the nail plate. Any topical preparation can be applied to the nail once every 2 to 3 days. And systemic antifungal drugs should be taken according to the following schemes:
  • Griseofulvin preparations (Griseofulvin, Griseofulvin Forte, etc.) in the first month of therapy, take 2-3 tablets three times a day every day. In the second month - 2 - 3 tablets 3 times a day every other day. From the third month until the end of treatment, Griseofulvin should be taken 2 to 3 tablets 3 times a day, twice a week. With onychomycosis of the feet, preparations are taken for 9-18 months, for hands - 4-6 months.
  • Ketoconazole preparations (Mycozoral, Nizoral, Oronazole, etc.) should be taken 200 mg once a day with meals for 4 to 6 months for onychomycosis of the hands and 8 to 12 months for a fungal infection of the toenails.
  • Itraconazole preparations (Orungal, Irunin, Itrazol, etc.) for the treatment of onychomycosis of the feet and hands, they are used according to two schemes - continuous and pulse. With a continuous regimen, it is necessary to take 200 mg of itraconazole once a day for 3 months every day. With pulse therapy, itraconazole is taken for a week at 200 mg twice a day. Then make a break lasting 3 weeks and repeat the 7-day course of taking the drug. For the treatment of onychomycosis of the hands, 2 cycles of pulse therapy are sufficient (2 seven-day courses of administration with one break between them), and 3-4 cycles of the legs.
  • Terbinafine preparations (Lamisil, Terbinafine, Atifin, Bramisil, etc.) should be taken at 250 mg once a day for 1.5 months with onychomycosis of the hands, and 3 months with lesions of the feet.
  • Fluconazole preparations (Diflucan, Flucostat, Fluconazole, etc.) must be taken 150 mg once a week for six months with onychomycosis of the hands and 8-12 months with lesions of the feet.
For therapy, you can choose any of the presented regimens, however, it must be remembered that the most effective drugs are itraconazole, terbinafine and fluconazole. It is advisable for topical application to the nail plate to pick up some preparation in the form of an ointment, gel or spray containing the same active substance as the tablets taken orally. Usually, the same antifungal drug is available in forms for both local (cream, gel, ointment) and systemic (tablets, capsules) use, so choosing the right pair is not difficult.

Drugs for the treatment of onychomycosis

Drugs for the treatment of onychomycosis include antifungal agents for local and systemic use. Preparations for topical application are intended for application directly to the nail plate and are available in the form of various ointments, gels, sprays, lotions, varnishes, etc. Preparations for systemic use are intended for oral administration and are available in the form of tablets or capsules.

Preparations for systemic use

Preparations for systemic use in onychomycosis are shown in the table, where the international name of the active substance is indicated in the left column, and the commercial names of preparations containing this active ingredient are listed in the right, opposite rows.
Name of the active substance Commercial names of drugs under which
they are sold in pharmacies
GriseofulvinGriseofulvin
Griseofulvin Forte
Fulcin
KetoconazoleKetoconazole tablets
Mycozoral tablets
Nizoral tablets
Oronazole tablets
Funginok tablets
Fungistab tablets
Fungavis tablets
Fungolon
ItraconazoleIrunin capsules
Itrazol capsules
Itraconazole capsules
Canditral capsules
Miconihol capsules
Orungal capsules and oral solution
Orungamine capsules
Orunite capsules
Rumikoz capsules
Tecnazol capsules
TerbinafineAtifin tablets
Binafin tablets
Bramisil tablets
Lamisil tablets
Terbizil tablets
Terbinafine tablets
Terbinox tablets
Terbifin tablets
Thermikon tablets
Tigal-Sanovel tablets
Tebikur tablets
Fungoterbin tablets
Tsidokan tablets
Exiter tablets
Exifin tablets
FluconazoleVero-Fluconazole capsules
Diflazon capsules
Difluzol capsules
Diflucan capsules and powder
Medoflucon capsules
Mycomax capsules, syrup
Mycosist capsules
Mycoflucan tablets
Nofung capsules
Procanazole capsules
Fangiflu capsules
Fluzol capsules
Flucoside capsules
Fluconazole capsules, tablets
Fluconorm capsules
Flunol capsules
Forkan capsules
Funzol capsules
Ciscan capsules

Ointments for the treatment of onychomycosis

Ointments used to treat onychomycosis are shown in the table, where the international name of the active substance is indicated in the left column. And in the right column there is a list of commercial names under which drugs containing this active substance are sold in pharmacies.

In addition to ointments, the table also lists other forms for topical use, such as gels, varnishes, sprays, lotions, etc.

Name of the active substance Commercial names of drugs
KetoconazoleDermazole cream
Mikoket ointment
Mycozoral ointment
Nizoral cream
Perchotal ointment
Sebozol ointment
clotrimazoleAmiclon cream
Imidil cream
Candibene cream
Candide cream and powder
Candizol cream
Canesten cream and spray
Canison cream and solution
Clotrimazole gel, cream and ointment
Funginal cream
Fungicide cream
MiconazoleDaktarin spray
Mycosone cream
BifonazoleBifasam cream
Bifonazole cream, powder and solution
Bifosin cream, powder, spray and solution
Mycospor cream and solution
EconazolePevaril
IsoconazoleTravogen cream
Travocort cream
TerbinafineAtifin cream
Binafin cream
Lamisil cream, spray, gel
Spray laminator
Myconorm cream
Tebikur cream
Terbized-Agio cream
Terbizil cream
Terbix cream and spray
Terbinafine cream
Terbinox cream
Terbifin cream and spray
Thermicon cream and spray
Ungusan cream
Fungoterbin cream and spray
Exifin cream
Exiter cream
NaftifinExoderil cream and solution
AmorolfineLoceryl
CyclopyroxolamineBatrafen gel, cream and varnish
Fongial cream and varnish

Laser treatment

Laser irradiation of peripheral blood arteries is an additional method of physiotherapy that can be used in combination with antifungal drugs as part of the complex treatment of onychomycosis. Only the use of laser irradiation will not cure a fungal infection of the nails, since this procedure improves blood flow to the tissues and, accordingly, facilitates the delivery of the antifungal drug taken to the most inaccessible cells. But if the antifungal drug is not taken, then simply improving blood flow will only accelerate nail growth.

Onychomycosis - photo


The photograph shows the appearance of nails with various forms of onychomycosis.

Shoe treatment for onychomycosis

Shoes for onychomycosis in order to disinfect and remove fungal spores are recommended to be treated with the following substances:
  • 25% formalin solution;
  • 40% acetic acid solution;
  • 0.5% chlorhexidine solution;
  • Spray Daktarin.
Shoes inside and out must be wiped with a swab moistened with any indicated solution, especially carefully treating the insoles and side surfaces. Then the swab is put into the toe of the shoe, packed in a plastic bag, carefully tied and left for a day. After that, the shoes are removed from the bag, the swab is removed, wiped with ammonia and ventilated to remove the specific smell.

Socks, tights, stockings and other fabrics can be disinfected by boiling in a 2% soap and soda solution for 20 minutes. Manicure accessories are disinfected by immersion in alcohol and then calcined over a fire.

There are contraindications. Before use, you should consult with a specialist.